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Associate Specialist - Cromer Lab
Department of Surgery
University of California, San Francisco

The Department of Surgery seeks an Associate Specialist to support the research program of Dr. Kyle Cromer in the Broad Center for Regeneration Medicine & Stem Cell Research at UCSF. The Cromer Lab studies hematopoietic disorders and develops advanced genome engineering strategies that integrate CRISPR-mediated editing with synthetic biology tools. These approaches enable the introduction of novel, programmable functions into human cells for therapeutic applications, including:

• Engineering red blood cells to produce and/or secrete therapeutic proteins into the bloodstream
• Developing synthetic signaling tools that confer a selective advantage to therapeutically relevant cell types
• Introducing inducible or autonomous safety switches to prevent expansion or differentiation of unwanted cell populations

The Associate Specialist will participate in all aspects of molecular tool development, including design, cloning, validation, and optimization of genome editing constructs, as well as execution of in vitro and in vivo studies to evaluate these systems in clinically relevant hematopoietic models. The overarching goal of this work is to overcome key bottlenecks in gene therapy, including limitations in editing precision, delivery efficiency, and durable engraftment. The Associate Specialist will also contribute to the development and operationalization of strategic research initiatives that advance the laboratory’s translational objectives, including preclinical validation and preparation for regulatory submission.

The Associate Specialist will be expected to perform the below job responsibilities:

• Design and execute genome engineering experiments in human hematopoietic stem & progenitor cells
• Perform advanced molecular biology, cell culture, bioinformatic, and functional assays
• Lead and manage in vivo mouse transplantation studies, including use of immunodeficient and humanized models
• Analyze and interpret data, prepare figures and manuscripts, and contribute to grant writing
• Mentor junior trainees and contribute to scientific training activities within the lab
• Assist with regulatory documentation and compliance for gene therapy-related research

The Associate Specialist will work in a collaborative and multidisciplinary environment with MD and PhD scientists across UCSF and partner institutions.

Specialists appointed at the Associate rank must have a master’s degree (or equivalent degree) in Genetics, Stem Cell Biology, Bioengineering, Molecular Biology, or a related field or at least 5-10 years of research experience. A Ph.D. degree (or equivalent) in Genetics, Stem Cell Biology, Bioengineering, Molecular Biology, or a related field, or 10 or more years of research experience is preferred.

UC San Francisco seeks candidates whose experience, teaching, research, and community services that have prepared them to contribute to our commitment to excellence.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $75,600 - $88,000.

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As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.
• “Misconduct” means any violation of the policies or laws governing conduct at the applicant’s previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, or discrimination, as defined by the employer.
• UC Sexual Violence and Sexual Harassment Policy
• UC Anti-Discrimination Policy
• APM - 035: Affirmative Action and Nondiscrimination in Employment