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Specialist – Cell Engineering (Krogan Lab, UCSF)

We are seeking a creative, collaborative, and motivated Specialist to join the UCSF Quantitative Bioscience Institute (QBI) Research and Engineering to Accelerate Discovery (READY) Center Team. This role will focus on utilizing cutting-edge CRISPR gene editing methods to support cell engineering projects that are part of a larger research platform designed to study disease biology at the cellular level and identify new therapeutic modalities. The ideal applicant has a strong technical background in CRISPR genome engineering and cell culture, with a passion for working with cross-functional teams in a fast-paced environment to deliver high quality results.

What You'll Do
• Utilize cutting-edge CRISPR gene editing methods for cell engineering projects that support the discovery platform and our research goals.
• Help us to continually improve our cell engineering capabilities for a wide range of cell types, including immortalized cell lines, primary cells, and stem cells.
• Work collaboratively and maintain strong working relationships with both the cell engineering and research teams.
• Stay current on advances in the genome engineering and disease research fields, and present relevant findings during internal forums.
• Share your knowledge, expertise, and results by maintaining excellent team communication.

The QBI (http://qbi.ucsf.edu) is a highly collaborative laboratory focusing on the molecular networks underpinning infectious disease, carcinogenesis, and psychiatric disorders. Our ideal applicant is a problem solver with a positive attitude, excellent organizational and interpersonal skills, and the ability to learn and implement methodology efficiently.

We are hiring full-time Specialists for this project with qualifications from junior to full Specialist (see qualifications below). Candidate’s CV and/or cover letter must state required qualifications (or if pending) upon submission. Candidates must meet all Required Qualifications by the time of hire.

Required Qualifications:
• Jr. Specialist rank: Bachelor's degree in biological sciences or an appropriate scientific field.
• Assistant Rank: Master’s degree, or Bachelor’s degree and 3 or more years of work experience in a relevant field of biological research.
• Associate Rank: Master's degree, or Bachelor's degree and 5-10 years of work experience in a relevant field of biological research.
• Full Specialist rank: PhD or 10+ years of work experience in a relevant field of biological research.

• Experienced in mammalian cell culture with excellent aseptic technique and proficiency in clonal isolation.
• Experienced in current molecular biology methods (e.g., DNA extraction, PCR, DNA design software).
• Excellent communication skills and the ability to present relevant scientific findings to an audience of research scientists.
• Able to work independently and meet deadlines; recognize and resolve problems while maintaining a high level of organization.
• Highly adaptable with a friendly and collaborative work ethic.

Preferred Qualifications:
• Experienced in cell culture of human iPSCs with proficiency in clonal isolation.
• Experience with automation platforms for use in cell engineering.
• Experienced in the use CRISPR gene editing technology for generating gene knockouts and knock-ins (SNVs, gene tags, etc.) in human cell lines. Design of gene editing strategies is a plus.
• Familiarity with sequencing (Sanger, NGS) and biochemical assays (PCR, etc.) for quantifying CRISPR editing outcomes.

Please apply online at https://aprecruit.ucsf.edu/JPF04784, with a CV, a cover letter, and three reference contacts.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$181,800.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.