Applications received after this date will be reviewed by the search committee if the position has not yet been filled.
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
University of California, San Francisco
The Department of Pharmaceutical Chemistry seeks candidates for a Specialist position in the England laboratory. This position will be hired at the Junior, Assistant, or Associate level dependent upon the applicant’s experience. Dr. England’s research is focused on developing chemical tools for decoding biology and advancing medicine. The laboratory is currently developing synthetic small molecules to control the activity of nuclear receptors, a class of intracellular proteins that regulate gene expression in response to endogenous hormones and other small molecules. These receptors play critical roles in human development, physiology, and disease and have proven to be effective therapeutic drug targets. Under general direction, the incumbent will develop and study the activity of ligands targeting the nuclear receptor Nurr1, a potential therapeutic target for Parkinson’s disease. This is a research position. Applicants are expected to be able to work independently and possess the ability to troubleshoot experiments when they don’t work. In addition, the applicant must possess the ability to analyze their data and clearly communicate their research techniques and results in written and oral formats suitable for publication. Specific activities associated with the position include, but are not limited to, the following:
- Preparation of high quality/purity protein samples. Technical skill set: primer design for PCR, DNA subcloning and mutagenesis, over-expression and purification of protein.
- Disulfide-trapping Screening. Technical skill set: robust pipetting skills, analysis of screening data (library hits).
- Chemical synthesis of small molecules (library hits and analogs). Technical skill set: chemical reactions and purification of crude products via column chromatography, analysis of purified material via LC-MS and NMR.
- In vitro assays of ligand affinity: Technical skill set: differential scanning fluorimetry assays (DSF), direct binding assays (SPR).
- Specialists appointed at the Junior level must possess at least a BA/BS degree (or equivalent degree) in chemistry (or related field).
- Specialists appointed at the Assistant or Associate rank must possess a Master’s degree (or equivalent degree) in chemistry or at least 5 years of research experience in the related field.
- One or more years prior experience in a chemistry or chemical biology lab
- Excellent organizational skills
- Excellent written and verbal presentation skills
- Experience with Excel, Prism or KaleidaGraph, WORD, Powerpoint, Adobe Illustrator
- MS or equivalent degree in chemistry (or related field)
Applicants should submit a cover letter and a curriculum vitae. Please apply online and submit these documents along with the contact information for three references to: https://aprecruit.ucsf.edu/apply/JPF01810.
Salary and rank will be commensurate with the applicant’s experience and training.
UCSF seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment of diversity and excellence.
The University of California is an Equal Opportunity/Affirmative Action Employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
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