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Specialist in Structural Biology*

Application Window

Open date: January 18, 2023

Most recent review date: Friday, Nov 17, 2023 at 11:59pm (Pacific Time)
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.

Final date: Thursday, Jul 18, 2024 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Position description

Specialist in Structural Biology*

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking an outstanding and motivated individual to join our cutting- edge research institute aimed at discovering new therapies for neurodegenerative diseases. The successful incumbent will work as a cryo-electron microscopy (cryo-EM) specialist focused on deciphering the structural basis for neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), multiple system atrophy (MSA) and Parkinson’s disease (PD). This will involve solving high-resolution cryo-EM structures of disease-relevant filaments, including co-structures with therapeutic targets.

The IND cryo-EM facility is state of the art and includes a Titan Krios, Glacios, and L120C TEM instruments. An additional advanced facility that will house new instruments including a Krios G4 and Helios Hydra plasma FIB-SEM is currently in development for next year. The IND is directed by Nobel Laureate Dr. Stanley Prusiner and located at the Sandler Neurosciences Center at UCSF’s Mission Bay campus, a world-renowned hub of biomedical research and discovery.

The successful applicant will be an expert structural biology researcher with experience in the determination of atomic-resolution structures of protein macromolecules. They will be responsible for applying these methods and skills to support drug discovery and other research efforts at the IND. The incumbent will be a skilled communicator and collaborate with team members across disciplines at the IND and UCSF to advance cryo-EM research efforts to understand the structural basis of neurodegenerative disease-relevant protein macromolecules.

Personal Qualifications

  • Possess a high sense of responsibility for his or her own career development, as well as for the wellbeing of our organization.
  • Willingness to receive training and guidance from senior investigators as well as serve as a mentor to trainees on the project.

Education and Training Qualifications:

  • Ph.D. degree in Biophysics or related field.

Technical Qualifications

  • 2+ years of experience in cryo-EM including sample preparation, microscope operation, data collection, computational analysis, and 3D structure determination of protein macromolecules OR 2+ years of experience in high-resolution protein structure determination using x-ray crystallography or NMR with additional exposure to cryo-EM methodology.


  • Experience using cryo-EM data collection and processing software including SerialEM, Scipion, RELION, cryoSPARC or related package.
  • Experience in protein expression, purification, and biochemistry OR purification of amyloid filaments from human and/or animal tissue.
  • Experience modeling protein-ligand complexes, including the use of Phenix, COOT, or related software.
  • Experience with density functional theory (DFT) or other computational modeling methods.

Candidates must meet the required qualifications at the time of appointment. Candidate's CV or cover letter must state qualifications (or if pending) upon submission.

This is a full-time position with excellent benefits. Salary is dependent upon experience.

Please apply online at, with a CV, cover letter, statement of research, a statement of contributions to diversity, and 3 references.

  • Rank will be commensurate with background, experience, and work history.

See Table 24B ( for the salary range for this position. A reasonable estimate for this position is $83,100-$173,900.

Application Requirements

Document requirements
  • Curriculum Vitae - CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.).

  • Cover Letter

  • Statement of Research (Optional)

  • Statement of Teaching (Optional)

  • Statement of Contributions to Diversity - Please see the following page for more details:

  • Misc / Additional (Optional)

Reference requirements
  • 3 required (contact information only)

About UC San Francisco

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Job location

San Francisco, CA