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Specialist in Cryo-EM Structural Biology

Application Window

Open date: December 14, 2022

Most recent review date: Thursday, Dec 29, 2022 at 11:59pm (Pacific Time)
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.

Final date: Friday, Jun 14, 2024 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Position description

Specialist in Cryo-EM Structural Biology

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking an outstanding and motivated individual to join our cutting-edge research institute aimed at discovering new therapies for neurodegenerative diseases. The successful incumbent will contribute and help manage our cryo-electron microscopy (cryo-EM) structural biology program focused on deciphering the structural basis for neurodegenerative diseases, including, Alzheimer’s disease (AD), frontotemporal dementia (FTD), multiple system atrophy (MSA) and Parkinson’s disease (PD). This position is a part of the Institutes broad focus on developing a highly skilled and multidisciplinary team to discover the causes of disease, and develop effective pharmacologic treatments, cures and diagnostic markers for these diseases. The IND cryo-EM facility is state of the art and includes a Titan Krios, Glacios, and L120C transmission EM instruments. Additional advanced instruments including a Krios G4 and plasma FIB-SEM have recently been purchased as a part of plans to develop an additional 3,000 sq. ft. facility in 2022. The IND is directed by Nobel Laureate Dr. Stanley Prusiner and located at the Sandler Neurosciences Center at UCSF’s Mission Bay campus, a world-renowned hub of biomedical research and discovery.

The successful applicant will be an experienced structural biology researcher with expertise in cryo-EM research and in the operation and support of an electron microscope facility, including personnel training, data collection and processing. They will be responsible for developing and applying these methods and skills to support the operation of the IND cryo-EM facility and ongoing research efforts. This will additionally include collaboration and research with faculty and research teams on groundbreaking projects. Thus, the incumbent will be a skilled communicator with interests in working as a team with members across disciplines at the IND to advance cryo-EM research efforts to understand the structural basis of neurodegenerative disease-relevant protein macromolecules.

Personal Qualifications
Required:
• Possess a high sense of responsibility for his or her own career development, as well as for the wellbeing of our organization.
• Willingness to receive training and guidance from senior investigators as well as serve as a mentor to trainees on the project.

Education and Training Qualifications:
Required:
• Ph.D. degree in Biophysics or related field.
• Two-years minimum postdoctoral experience in cryo-electron microscopy.

Technical Qualifications
Required:
• 2+ years of experience in cryo-EM including sample preparation, microscope operation, data collection, computational analysis, and 3D structure determination of protein macromolecules.
• Demonstrated experience in user training and support for the operation of high-resolution cryo-EM instruments.
Preferred:
• Expertise in cryo-EM computational software including RELION, cryoSPARC and/or cisTEM.
• Biochemistry expertise including protein purification and analysis by in vitro methods.

This is a full-time position with excellent benefits. Salary is dependent upon experience.

Candidates must meet the required qualifications at the time of appointment. Candidate's application materials must state qualifications (or if pending) upon submissions.
This is a full-time position with excellent benefits. Salary is dependent upon experience.

Please apply online at https://aprecruit.ucsf.edu/JPF04309, with a CV, cover letter (including a brief statement about your research background and experiences in training or mentoring in cryoEM as well as your career goals [or interests in this position]; formal classroom teaching experience is not required), and 3 references.

See Table 24B (https://www.ucop.edu/academic-personnel-programs/_files/2022-23/july-2022-salary-scales/t24-b.pdf) for the salary range for this position. A reasonable estimate for this position is $83,100-$173,900.

Application Requirements

Document requirements
  • Curriculum Vitae - CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.).

  • Cover Letter - (including a brief statement about your research background and experiences in training or mentoring in cryoEM as well as your career goals [or interests in this position]; formal classroom teaching experience is not required)

  • Statement of Research (Optional)

  • Statement of Teaching (Optional)

  • Statement of Contributions to Diversity - Please see the following page for more details: https://diversity.ucsf.edu/contributions-to-diversity-statement
    (Optional)

  • Misc / Additional (Optional)

Reference requirements
  • 3 required (contact information only)

About UC San Francisco

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Job location

San Francisco, CA