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Senior Research Specialist (Genomic Sequencing) – Feng Lab

Application Window

Open date: October 26, 2022

Most recent review date: Thursday, Nov 10, 2022 at 11:59pm (Pacific Time)
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.

Final date: Friday, Apr 26, 2024 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Position description

Senior Research Specialist (Genomic Sequencing) – Feng Lab
University of California, San Francisco
Department of Radiation Oncology


The Feng Laboratory at the University of California, San Francisco is seeking to recruit an outstanding candidate to fill a Senior Research Specialist position. The ideal candidate will be able to reliably perform next generation sequencing and CRISPR screening. The candidate will also independently develop, implement, and manage new techniques in genomics, transcriptomics and epigenomics applied to small clinical specimens. Applicants should be well organized, focused on technical precision and reproducibility, and demonstrate independence and responsibility for their workflows. The position will also involve teamwork across numerous ares of expertise including clinical research management, NGS and other molecular workflows, and computational biology.

Research in the Feng Lab focuses on (1) identifying molecular drivers of prostate cancer pathogenesis, (2) understanding the mechanisms that contribute to disease progression and metastasis, and (3) developing novel therapeutic strategies. Our lab utilizes cancer genomics, cell biology, CRISPR screening, and mouse modeling approaches to answer fundamental questions underlying prostate cancer biology, with the goal of translating discoveries from the lab into the clinic.

We work collaboratively with basic scientists, computational biologists, pathologists, and oncologists at the UCSF Helen Diller Cancer Center. Please refer to for additional details.

Job responsibilities include but are not limited to:
• Perform next generation sequencing (NGS) library preparations with with high precision and reproducibility with a high degree of autonomy
• Creating single guide RNA (sgRNA) arrays and new CRISPR screens
• Develop protocols for emerging methodologies in RNA, DNA, and epigenomic spaces, applied to small clinical specimens, includeing single cell experiments.
• Work independently with high precision, organization and reproducibility in clinical research workflows.
• Manage projects that stem from our clinical research program, including coordination with biopsy operations at remote sites, local biorepository operations, and coordination with UCSF researchers and collaborating outside labs for sample acquisition and processing.

Required qualifications:
• Applicants need to be self-motivated, fast learners, critical thinkers, and enthusiastic about science and medicine.
• Demonstrated ability to work both as part of a team and independently.
• Strong ability to problem solve and troubleshoot experiments.
• Applicants will need to be highly technical and detail oriented.
• Specialists appointed at:
o Full rank must possess a PhD degree or at least ten or more years of experience in the relevant specialization.

Preferred qualifications:
• Experience developing and running NGS workflows
• Previous work with clinical specimens, specifically frozen tissue and blood-based derivatives is a plus
• Prior experience in lab organization and project management, particularly within the field of cancer genomics
• Demonstrated prior success and independence with technical protocols, critical problem solving skills and project management.

Salary and appointment will be commensurate with the applicant's experience and training. This position is available immediately. Please apply online at Applicants' materials must list current and/or pending qualifications upon submission.

Application Requirements

Document requirements
  • Curriculum Vitae - CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.).

  • Cover Letter

  • Statement of Research (Optional)

  • Statement of Teaching (Optional)

  • Statement of Contributions to Diversity - Please see the following page for more details:

  • Misc / Additional (Optional)

About UC San Francisco

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Job location

San Francisco, CA