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HDX-MS Researcher

Recruitment Period

Open date: January 16th, 2020

Last review date: Friday, Jan 31, 2020 at 11:59pm (Pacific Time)
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.

Final date: Friday, Jul 16, 2021 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.


We are recruiting a highly motivated and collaborative Assistant or Associate Researcher to establish an HDX pipeline in the Krogan lab at UCSF. The Krogan lab utilizes proteomic and genomic systems biology techniques to study disease areas, including cancer, infectious disease, cardiovascular disease, and psychiatric conditions.

The successful candidate will be experienced with mass spectrometry-based structural proteomic techniques, specifically HDX. Familiarity with mass spectrometer instrument operation and maintenance is preferred. A motivation to develop and optimize new structural proteomic technologies will be beneficial for this position.

Professor Nevan Krogan has a well-established team of young and talented scientist working from the world renowned University of California - San Francisco (UCSF) and J. David Gladstone Institutes, both based in San Francisco, California. The success of the Krogan lab has largely been based on collaborations with the world’s top scientists who have been brought together through three of our main initiatives: the Host Pathogen Map Initiative (HPMI) (, the Cancer Cell Map Initiative (CCMI) ( and the Psychiatric Cell Map Initiative (PCMI) ( The HDX structural studies will be integrated into the main lab and expected to contribute to overall goals of the various mapping initiatives.

Responsibilities and Duties:

  • Manage, organize and develop HDX related projects in the Krogan lab, working collectively towards goals in the Krogan lab cell mapping initiatives.
  • Operate and maintain lab instruments involved in HDX data acquisition.
  • Analysis of HDX data.
  • Communicate and share research findings through written and oral reports and weekly lab meetings


  • PhD in Chemistry, Biochemistry, Biophysics, Molecular Biology, or related field
  • Hands on experience and technical expertise with HPLCs and mass spectrometers
  • Expertise in HDX techniques and data analyses.
  • Strong communication and writing skills.
  • Highly collaborative with excellent organizational skills and the ability to prioritize effectively.
  • Capable and interested in developing and optimizing new analytical pipelines.

Preferred Qualifications:

  • Previous hands on experience with Thermo Q Exactive and/or Thermo Lumos instruments.
  • Hands on experience with robotic sample preparation equipment (i.e. LEAP PAL system).

UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Please apply online at, with a CV, cover letter, and two references (contact information only).

Job location

San Francisco, CA


Document requirements
  • Curriculum Vitae - Your most recently updated C.V.

  • Cover Letter

  • Statement of Research (Optional)

  • Statement of Teaching (Optional)

  • Statement of Contributions to Diversity (Optional)

  • Misc / Additional (Optional)

Reference requirements
  • 2 required (contact information only)