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Professional Researcher- Esensten Lab

Recruitment Period

Open date: November 5th, 2019

Last review date: Wednesday, Nov 20, 2019 at 11:59pm (Pacific Time)
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.

Final date: Wednesday, May 5, 2021 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Description

The Department of Laboratory Medicine is seeking a Researcher in the Professional Research Series. In this position, you will serve as program manager for Treg therapy process development for the UCSF Regulatory T Cell (Treg) Group. You will develop CRISPR-Cas9 based approaches to manufacture regulatory T cell based cellular therapies in preparation for first-in-human clinical trials at UCSF. This job will require daily hands-on laboratory work with human T cells and creativity in solving problems that arise during product development. You will have supervisory responsibility for other scientists and oversight over cellular therapy manufacturing activities. You will report directly to the medical director of the Treg group, Dr. Jonathan Esensten. You will also work closely with the group of Dr. Alex Marson.

Translation of preclinical advances into cellular therapy treatments requires a team approach and you will need to be an effective communicator and a team player. You will work closely with basic scientists, physicians, experts in quality assurance, and experts in regulatory affairs to optimize each step in cell therapy manufacturing. The end goal is to develop a GMP-compliant manufacturing process using CRISPR-Cas9 technology in Treg and then transfer that process to a clinical GMP laboratory for clinical scale manufacturing and completion of a clinical trial. You will oversee and participate in GMP manufacturing as needed. Please see treg.ucsf.edu for more information about our group.

Required Qualifications:
• Professional Research series appointees at the rank of Researcher must have a terminal degree (MD or PhD)
• At least 2 years of experience in cellular therapy process development
• Experience performing flow cytometry
• Experience with T cell isolation and manipulation
• Experience with cellular therapy or biologic drug development
• Understanding of cGMP requirements in drug manufacturing

Preferred Qualifications:
• PhD degree in cellular immunology or molecular biology

Screening of applicants will begin immediately and will continue as needed throughout the
recruitment period. Salary and rank will be commensurate with the applicants experience and training. Please apply online at https://aprecruit.ucsf.edu/JPF02753.

UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive
consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Job location

San Francisco, CA

Requirements

Document requirements
  • Curriculum Vitae - Your most recently updated C.V.

  • Cover Letter

  • Statement of Research (Optional)

  • Statement of Teaching (Optional)

  • Statement of Contributions to Diversity (Optional)

  • Misc / Additional (Optional)

Reference requirements
  • 2 required (contact information only)