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Molecular Biology and Protein Chemist

Recruitment Period

Open date: May 25th, 2018
Last review date: Saturday, Jun 23, 2018 at 11:59pm (Pacific Time)
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.
Final date: Monday, Nov 25, 2019 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.


Molecular Biology and Protein Chemist
Assistant, Associate, or Full Specialist Series
Gross Lab, Department of Pharmaceutical Chemistry
University of California, San Francisco

The Laboratory of Professor John Gross in the Department of Pharmaceutical Chemistry has an open position for a molecular biologist/protein biochemist. The Gross Lab’s research is focused on reconstituting and resolving host pathogen conflicts. We employ advanced tools for this work ranging from X-ray crystallography to EM, which require complexes to be purified from endogenous sources or reconstituted from recombinant purified components. The successful candidate will work within the UCSF HARC center to express and purify target complexes using a variety of eukaryotic expression systems. Primary methods for expression of target proteins will be carried out using mammalian cell culture in suspension. The candidate will have the opportunity to work with antigen binding fragments (Fabs), which have the potential to be used in HIV immunotherapy. Accordingly, the candidate will have experience with mammalian cell culture and molecular biology in addition to basic techniques utilized modern protein chemistry.

Required Qualifications

  • Specialists appointed at the Assistant or Associate rank must have a minimum of a master’s degree (or equivalent) in life sciences field or at least five years of research experience
  • Specialists appointed at the Full rank must possess a terminal degree (or equivalent degree) in life sciences field or at least ten years of research experience
  • Experience in mammalian cell culture, molecular biology and/or protein chemistry
  • Interest and experience working in a team research environment
  • Strong written and communication skills

Preferred Qualifications

  • PhD (or equivalent) in life sciences or related field
  • Expertise working with a variety of eukaryotic cell lines
  • Molecular biology, mammalian cell culture and techniques, qPCR, immunoblot, in vitro transcription and translation, microscopy, plasmid vector construction, DNA and RNA sequencing
  • Experience with protein purification on small and preparative scale
  • Experience with enzyme biochemistry and quantitative analysis of activity

Salary will be commensurate with the applicant’s experience and training.

UCSF seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment of diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Applicants should submit a brief cover letter and a curriculum vitae. Please apply online and submit these documents along with the contact information for at least two references to:

Job location

San Francisco, CA


Document requirements
  • Curriculum Vitae - Your most recently updated C.V.

  • Cover Letter

  • Statement of Research (Optional)

  • Statement of Teaching (Optional)

  • Statement of Contributions to Diversity (Optional)

  • Misc / Additional (Optional)

Reference requirements
  • 2 required (contact information only)